Naked Plasmid DNA Formulation: Effect of Different Disaccharides on Stability after Lyophilisation

Since plasmid DNA (pDNA) is unstable in solution, lyophilisation can be used to increase product shelf life. To prevent stress on pDNA molecules during lyophilisation, cryo- and lyoprotectants have to be added to the formulation. This study assessed the effect of disaccharides on naked pDNA stabilit...

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Detalles Bibliográficos
Autores principales: Quaak, Susanne G. L., Haanen, John B. A. G., Beijnen, Jos H., Nuijen, Bastiaan
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850488/
https://www.ncbi.nlm.nih.gov/pubmed/20204715
http://dx.doi.org/10.1208/s12249-010-9391-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850488/
https://www.ncbi.nlm.nih.gov/pubmed/20204715
http://dx.doi.org/10.1208/s12249-010-9391-2

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