Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

AIMS/HYPOTHESIS: Impaired nitric oxide (NO)-dependent vasorelaxation plays a key role in the development of diabetic vascular complications. We investigated the effect of hyperglycaemia on impaired vasoreactivity and a putative role therein of the AGE precursor methylglyoxal. METHODS: The effects of...

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Detalles Bibliográficos
Autores principales: Brouwers, O., Niessen, P. M., Haenen, G., Miyata, T., Brownlee, M., Stehouwer, C. D., De Mey, J. G., Schalkwijk, C. G.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850524/
https://www.ncbi.nlm.nih.gov/pubmed/20186387
http://dx.doi.org/10.1007/s00125-010-1677-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850524/
https://www.ncbi.nlm.nih.gov/pubmed/20186387
http://dx.doi.org/10.1007/s00125-010-1677-0

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