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Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

AIMS/HYPOTHESIS: Impaired nitric oxide (NO)-dependent vasorelaxation plays a key role in the development of diabetic vascular complications. We investigated the effect of hyperglycaemia on impaired vasoreactivity and a putative role therein of the AGE precursor methylglyoxal. METHODS: The effects of...

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Detalles Bibliográficos
Autores principales:	Brouwers, O., Niessen, P. M., Haenen, G., Miyata, T., Brownlee, M., Stehouwer, C. D., De Mey, J. G., Schalkwijk, C. G.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850524/ https://www.ncbi.nlm.nih.gov/pubmed/20186387 http://dx.doi.org/10.1007/s00125-010-1677-0

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