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Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis

Autoreactive CD4(+) T lymphocytes play a vital role in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Since the discovery of T helper 17 cells, there is an ongoing debate whether T helper 1, T helper 17 or both subtypes of T lymphocytes are im...

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Detalles Bibliográficos
Autores principales: Kleiter, Ingo, Song, Jian, Lukas, Dominika, Hasan, Maruf, Neumann, Bernhard, Croxford, Andrew L., Pedré, Xiomara, Hövelmeyer, Nadine, Yogev, Nir, Mildner, Alexander, Prinz, Marco, Wiese, Elena, Reifenberg, Kurt, Bittner, Stefan, Wiendl, Heinz, Steinman, Lawrence, Becker, Christoph, Bogdahn, Ulrich, Neurath, Markus F., Steinbrecher, Andreas, Waisman, Ari
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850583/
https://www.ncbi.nlm.nih.gov/pubmed/20354004
http://dx.doi.org/10.1093/brain/awq039