Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing

BACKGROUND: Regulated autoprocessing of HIV Gag-Pol precursor is required for the production of mature and fully active protease. We previously reported that H69E mutation in a pseudo wild type protease sequence significantly (>20-fold) impedes protease maturation in an in vitro autoprocessing as...

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Detalles Bibliográficos
Autores principales: Huang, Liangqun, Hall, Alyssa, Chen, Chaoping
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850873/
https://www.ncbi.nlm.nih.gov/pubmed/20331855
http://dx.doi.org/10.1186/1742-4690-7-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850873/
https://www.ncbi.nlm.nih.gov/pubmed/20331855
http://dx.doi.org/10.1186/1742-4690-7-24

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