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Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Aβ1-40

BACKGROUND: Amyloid precursor protein (APP) is a ubiquitously expressed cell surface protein reported to be involved in mediating cell-cell or cell-matrix interactions. Prior work has demonstrated that APP co-localizes with β1 integrin in different cell types. METHODS: In an effort to determine the...

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Detalles Bibliográficos
Autores principales: Sondag, Cindy M, Combs, Colin K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850892/
https://www.ncbi.nlm.nih.gov/pubmed/20302643
http://dx.doi.org/10.1186/1742-2094-7-22