Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach

BACKGROUND: GPR17 is a hybrid G-protein-coupled receptor (GPCR) activated by two unrelated ligand families, extracellular nucleotides and cysteinyl-leukotrienes (cysteinyl-LTs), and involved in brain damage and repair. Its exploitment as a target for novel neuro-reparative strategies depends on the...

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Detalles Bibliográficos
Autores principales: Parravicini, Chiara, Abbracchio, Maria P, Fantucci, Piercarlo, Ranghino, Graziella
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850907/
https://www.ncbi.nlm.nih.gov/pubmed/20233425
http://dx.doi.org/10.1186/1472-6807-10-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850907/
https://www.ncbi.nlm.nih.gov/pubmed/20233425
http://dx.doi.org/10.1186/1472-6807-10-8

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