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Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach
BACKGROUND: GPR17 is a hybrid G-protein-coupled receptor (GPCR) activated by two unrelated ligand families, extracellular nucleotides and cysteinyl-leukotrienes (cysteinyl-LTs), and involved in brain damage and repair. Its exploitment as a target for novel neuro-reparative strategies depends on the...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850907/ https://www.ncbi.nlm.nih.gov/pubmed/20233425 http://dx.doi.org/10.1186/1472-6807-10-8 |