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Experimental evidence for a frustrated energy landscape in a 3-helix bundle protein family

Energy landscape theory is a powerful tool for understanding the structure and dynamics of complex molecular systems, in particular biological macromolecules1. The primary sequence of a protein defines its free energy landscape, and thus determines the folding pathway and the rate constants of foldi...

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Detalles Bibliográficos
Autores principales: Wensley, Beth G., Batey, Sarah, Bone, Fleur A. C., Chan, Zheng Ming, Tumelty, Nuala R., Steward, Annette, Kwa, Lee Gyan, Borgia, Alessandro, Clarke, Jane
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851140/
https://www.ncbi.nlm.nih.gov/pubmed/20130652
http://dx.doi.org/10.1038/nature08743