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Experimental evidence for a frustrated energy landscape in a 3-helix bundle protein family
Energy landscape theory is a powerful tool for understanding the structure and dynamics of complex molecular systems, in particular biological macromolecules1. The primary sequence of a protein defines its free energy landscape, and thus determines the folding pathway and the rate constants of foldi...
Autores principales: | Wensley, Beth G., Batey, Sarah, Bone, Fleur A. C., Chan, Zheng Ming, Tumelty, Nuala R., Steward, Annette, Kwa, Lee Gyan, Borgia, Alessandro, Clarke, Jane |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851140/ https://www.ncbi.nlm.nih.gov/pubmed/20130652 http://dx.doi.org/10.1038/nature08743 |
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