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Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules
Microtubule-perturbing drugs have become front line chemotherapeutics, inducing cell cycle crisis as a major mechanism of action. However, these agents exhibit pleiotropic effects on cells, and can induce apoptosis via other means. Paclitaxel, a microtubule-stabilizing agent, induces a caspase-depen...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851247/ https://www.ncbi.nlm.nih.gov/pubmed/19668227 http://dx.doi.org/10.1038/onc.2009.210 |