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Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress
The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the presence of hydroxyurea at low concentration. Mic...
Autores principales: | Utani, Koh-ichi, Kohno, Yuka, Okamoto, Atsushi, Shimizu, Noriaki |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851613/ https://www.ncbi.nlm.nih.gov/pubmed/20386692 http://dx.doi.org/10.1371/journal.pone.0010089 |
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