Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials

BACKGROUND: Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy. METHODS: Theoretical arguments are used to ident...

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Detalles Bibliográficos
Autores principales: White, Michael T, Griffin, Jamie T, Drakeley, Chris J, Ghani, Azra C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851701/
https://www.ncbi.nlm.nih.gov/pubmed/20331863
http://dx.doi.org/10.1186/1475-2875-9-82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851701/
https://www.ncbi.nlm.nih.gov/pubmed/20331863
http://dx.doi.org/10.1186/1475-2875-9-82

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