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Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials
BACKGROUND: Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy. METHODS: Theoretical arguments are used to ident...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851701/ https://www.ncbi.nlm.nih.gov/pubmed/20331863 http://dx.doi.org/10.1186/1475-2875-9-82 |