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Double Holliday Junctions are Intermediates of DNA Break Repair

Repair of DNA double-strand-breaks (DSBs) by homologous recombination is crucial for cell proliferation and tumor suppression. However, despite its importance, the molecular intermediates of mitotic DSB-repair remain undefined. The double Holliday Junction (dHJ), presupposed to be the central interm...

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Detalles Bibliográficos
Autores principales: Bzymek, Malgorzata, Thayer, Nathaniel H., Oh, Steve D., Kleckner, Nancy, Hunter, Neil
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851831/
https://www.ncbi.nlm.nih.gov/pubmed/20348905
http://dx.doi.org/10.1038/nature08868