Functional Recovery of Diabetic Mouse Hearts by Glutaredoxin-1 Gene Therapy: Role of Akt-FoxO Signaling Network

Recent studies suggest that glutaredoxin-1 (Glrx-1) may serve as therapeutic target for diabetic hearts. Since the level of reactive oxygen species (ROS) is increased in the pathologic hearts including ischemia/reperfusion (I/R) and diabetes, we assumed that upregulation of Glrx-1 could reduce the c...

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Detalles Bibliográficos
Autores principales: Lekli, Istvan, Mukherjee, Subhendu, Ray, Diptarka, Gurusamy, Narasimman, Kim, Yun Hong, Tosaki, Arpad, Engelman, Richard M., Ho, Ye-Shih, Das, Dipak K.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851834/
https://www.ncbi.nlm.nih.gov/pubmed/20182516
http://dx.doi.org/10.1038/gt.2010.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851834/
https://www.ncbi.nlm.nih.gov/pubmed/20182516
http://dx.doi.org/10.1038/gt.2010.9

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