Cargando…

Functional Recovery of Diabetic Mouse Hearts by Glutaredoxin-1 Gene Therapy: Role of Akt-FoxO Signaling Network

Recent studies suggest that glutaredoxin-1 (Glrx-1) may serve as therapeutic target for diabetic hearts. Since the level of reactive oxygen species (ROS) is increased in the pathologic hearts including ischemia/reperfusion (I/R) and diabetes, we assumed that upregulation of Glrx-1 could reduce the c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lekli, Istvan, Mukherjee, Subhendu, Ray, Diptarka, Gurusamy, Narasimman, Kim, Yun Hong, Tosaki, Arpad, Engelman, Richard M., Ho, Ye-Shih, Das, Dipak K.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851834/ https://www.ncbi.nlm.nih.gov/pubmed/20182516 http://dx.doi.org/10.1038/gt.2010.9

Ejemplares similares

Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection
por: Lekli, Istvan, et al.
Publicado: (2010)

Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium
por: Gurusamy, Narasimman, et al.
Publicado: (2010)

Regeneration of infarcted myocardium with resveratrol-modified cardiac stem cells
por: Gorbunov, Nikolai, et al.
Publicado: (2012)

Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein
por: Gurusamy, Narasimman, et al.
Publicado: (2009)

Reduction of reperfusion-induced ventricular fibrillation and infarct size via heme oxygenase-1 overexpression in isolated mouse hearts
por: Bak, Istvan, et al.
Publicado: (2010)

Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies
por: Barta, Tunde, et al.
Publicado: (2018)

Electrically-Induced Ventricular Fibrillation Alters Cardiovascular Function and Expression of Apoptotic and Autophagic Proteins in Rat Hearts
por: Czegledi, Andras, et al.
Publicado: (2019)

The Role of Autophagy and Death Pathways in Dose-dependent Isoproterenol-induced Cardiotoxicity
por: Gyongyosi, Alexandra, et al.
Publicado: (2019)

Beta-Carotene Affects the Effects of Heme Oxygenase-1 in Isolated, Ischemic/Reperfused Rat Hearts: Potential Role of the Iron
por: Csepanyi, Evelin, et al.
Publicado: (2022)

Autophagy: an adaptive physiological countermeasure to cellular senescence and ischaemia/reperfusion‐associated cardiac arrhythmias
por: Lekli, Istvan, et al.
Publicado: (2016)

Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium
por: Juhasz, Bela, et al.
Publicado: (2011)

The Impact of Moderate Chronic Hypoxia and Hyperoxia on the Level of Apoptotic and Autophagic Proteins in Myocardial Tissue
por: Gyongyosi, Alexandra, et al.
Publicado: (2018)

The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy
por: Zilinyi, Rita, et al.
Publicado: (2018)

Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications
por: Czompa, Attila, et al.
Publicado: (2018)

The Effects of Long-Term, Low- and High-Dose Beta-Carotene Treatment in Zucker Diabetic Fatty Rats: The Role of HO-1
por: Csepanyi, Evelin, et al.
Publicado: (2018)

Effects of Momordica charantia (Bitter Melon) on Ischemic Diabetic Myocardium
por: Czompa, Attila, et al.
Publicado: (2017)

Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells
por: Nghiem, Peter P., et al.
Publicado: (2017)

Homocysteine promotes cardiac fibrosis by regulating the Akt/FoxO3 pathway
por: Shi, Ying, et al.
Publicado: (2021)

Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese
por: Zhao, Ying, et al.
Publicado: (2014)

Ethanol increases phosphate-mediated mineralization and osteoblastic transformation of vascular smooth muscle cells
por: Oros, Melinda, et al.
Publicado: (2012)

FoxO Proteins in the Nervous System
por: Maiese, Kenneth
Publicado: (2015)

The FoxOs are in the ApoM house
por: Linton, MacRae F., et al.
Publicado: (2022)

Caveolin induces cardioprotection through epigenetic regulation
por: Das, Manika, et al.
Publicado: (2012)

Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation
por: Moriishi, Takeshi, et al.
Publicado: (2014)

Basic Pharmacological Characterization of EV-34, a New H(2)S-Releasing Ibuprofen Derivative
por: Gyöngyösi, Alexandra, et al.
Publicado: (2021)

Dataset on structure, stability and myocardial effects of a new hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety
por: Szőke, Kitti, et al.
Publicado: (2019)

Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice
por: Szőke, Kitti, et al.
Publicado: (2023)

Antioxidant Properties and Oxidative Transformation of Different Chromone Derivatives
por: Csepanyi, Evelin, et al.
Publicado: (2017)

FoxO gene family evolution in vertebrates
por: Wang, Minghui, et al.
Publicado: (2009)

Redox regulation of FoxO transcription factors
por: Klotz, Lars-Oliver, et al.
Publicado: (2015)

FoxO1 breaks diabetic heart
por: Nagao, Mototsugu, et al.
Publicado: (2013)

FoxO transcription factors in mitochondrial homeostasis
por: Cheng, Zhiyong
Publicado: (2022)

Arsenite-induced stress signaling: Modulation of the phosphoinositide 3′-kinase/Akt/FoxO signaling cascade()
por: Hamann, Ingrit, et al.
Publicado: (2013)

CHIP Regulates AKT/FoxO/Bim Signaling in MCF7 and MCF10A Cells
por: Lv, Yanrong, et al.
Publicado: (2013)

Idelalisib promotes Bim-dependent apoptosis through AKT/FoxO3a in hepatocellular carcinoma
por: Yue, Dan, et al.
Publicado: (2018)

Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway
por: Zhang, Hong, et al.
Publicado: (2020)

Organ-differential Roles of Akt/FoxOs Axis as a Key Metabolic Modulator during Aging
por: Kim, Dae Hyun, et al.
Publicado: (2021)

Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter
por: Tian, Yu-Nan, et al.
Publicado: (2020)

Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways
por: Chi, Meng-yi, et al.
Publicado: (2022)

Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect
por: Lee, Hsieh-Hsing, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_cua6be8800ncamdr90hkl10393