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Molecular Mechanism of Multivesicular Body Biogenesis by ESCRT Complexes
When internalized receptors and other cargo are destined for lysosomal degradation, they are ubiquitinated and sorted by the ESCRT complexes 0, I, II, and III into multivesicular bodies. Multivesicular bodies are formed when cargo-rich patches of the limiting membrane of endosomes bud inward by an u...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851844/ https://www.ncbi.nlm.nih.gov/pubmed/20305637 http://dx.doi.org/10.1038/nature08849 |