Metal-Free ALS Variants of Dimeric Human Cu,Zn-Superoxide Dismutase Have Enhanced Populations of Monomeric Species

Amino acid replacements at dozens of positions in the dimeric protein human, Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral sclerosis (ALS). Although it has long been hypothesized that these mutations might enhance the populations of marginally-stable aggregation-prone species respo...

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Detalles Bibliográficos
Autores principales: Svensson, Anna-Karin E., Bilsel, Osman, Kayatekin, Can, Adefusika, Jessica A., Zitzewitz, Jill A., Matthews, C. Robert
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852398/
https://www.ncbi.nlm.nih.gov/pubmed/20404910
http://dx.doi.org/10.1371/journal.pone.0010064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852398/
https://www.ncbi.nlm.nih.gov/pubmed/20404910
http://dx.doi.org/10.1371/journal.pone.0010064

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