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Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence

Four sequential Aspergillus fumigatus isolates from a patient with chronic granulomatous disease (CGD) eventually failing azole-echinocandin combination therapy were investigated. The first two isolates (1 and 2) were susceptible to antifungal azoles, but increased itraconazole, voriconazole and pos...

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Detalles Bibliográficos
Autores principales:	Arendrup, Maiken Cavling, Mavridou, Eleftheria, Mortensen, Klaus Leth, Snelders, Eveline, Frimodt-Møller, Niels, Khan, Humara, Melchers, Willem J. G., Verweij, Paul E.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852403/ https://www.ncbi.nlm.nih.gov/pubmed/20404915 http://dx.doi.org/10.1371/journal.pone.0010080

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