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Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling
OBJECTIVES: This study was designed to evaluate the interaction between aging and obesity on cardiac contractile and intracellular Ca(2+) properties. METHODS: Cardiomyocytes from young (4-mo) and aging (12- and 18-mo) male lean and the leptin deficient ob/ob obese mice were treated with leptin (0.5,...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852499/ https://www.ncbi.nlm.nih.gov/pubmed/20396382 http://dx.doi.org/10.1371/journal.pone.0010085 |