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Both Interaction Surfaces within Cohesin's Hinge Domain Are Essential for Its Stable Chromosomal Association
BACKGROUND: The cohesin complex that mediates sister chromatid cohesion contains three core subunits: Smc1, Smc3, and Scc1. Heterotypic interactions between Smc1 and Smc3 dimerization domains create stable V-shaped Smc1/Smc3 heterodimers with a hinge at the center and nucleotide-binding domains (NBD...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852676/ https://www.ncbi.nlm.nih.gov/pubmed/20153193 http://dx.doi.org/10.1016/j.cub.2009.12.059 |