The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel

Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter the channel pore’s outer vestibule and bind to multiple residues that control permeation. Radiolabeled toxins were key contributors to channel...

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Detalles Bibliográficos
Autores principales: Fozzard, Harry A., Lipkind, Gregory M.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852835/
https://www.ncbi.nlm.nih.gov/pubmed/20390102
http://dx.doi.org/10.3390/md8020219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852835/
https://www.ncbi.nlm.nih.gov/pubmed/20390102
http://dx.doi.org/10.3390/md8020219

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