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The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel
Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter the channel pore’s outer vestibule and bind to multiple residues that control permeation. Radiolabeled toxins were key contributors to channel...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Diversity Preservation International
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852835/ https://www.ncbi.nlm.nih.gov/pubmed/20390102 http://dx.doi.org/10.3390/md8020219 |