Cargando…

Mutagenicity of New Lead Compounds to Treat Sickle Cell Disease Symptoms in a Salmonella/Microsome Assay

A series of phthalimide derivatives planned as drugs candidates to treat the symptoms of sickle cell anemia were evaluated in a mutagenicity test using strains of Salmonella typhimurium TA100 and TA102, without and with addition of S9 mixture, with the aim to identify the best structural requirement...

Descripción completa

Detalles Bibliográficos
Autores principales:	dos Santos, Jean Leandro, Varanda, Eliana A., Lima, Lídia Moreira, Chin, Chung Man
Formato:	Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2010
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852868/ https://www.ncbi.nlm.nih.gov/pubmed/20386668 http://dx.doi.org/10.3390/ijms11020779

Ejemplares similares

Mutagenicity and antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays
por: Resende, Flávia Aparecida, et al.
Publicado: (2012)

Assessment of the In Vivo Genotoxicity of New Lead Compounds to Treat Sickle Cell Disease
por: dos Santos, Jean Leandro, et al.
Publicado: (2011)

Origanum majorana Essential Oil Lacks Mutagenic Activity in the Salmonella/Microsome and Micronucleus Assays
por: Dantas, Andrea dos Santos, et al.
Publicado: (2016)

Assessment of the Mutagenicity of Sediments from Yangtze River Estuary Using Salmonella Typhimurium/Microsome Assay
por: Liu, Li, et al.
Publicado: (2015)

Presentation of benzo(a)pyrene to microsomal enzymes by asbestos fibers in the Salmonella/mammalian microsome mutagenicity test.
por: Szyba, K, et al.
Publicado: (1983)

Mutagenicity of Flavonoids Assayed by Bacterial Reverse Mutation (Ames) Test
por: Resende, Flavia Aparecida, et al.
Publicado: (2012)

Mutagenic and Genotoxic Effect of Hydroxyurea
por: Santos, Jean L., et al.
Publicado: (2011)

Formulation, characterization, cytotoxicity and Salmonella/microsome mutagenicity (Ames) studies of a novel 5-fluorouracil derivative
por: Köksal Karayildirim, Çinel, et al.
Publicado: (2018)

Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity
por: Mininel, Francisco José, et al.
Publicado: (2014)

Characterization and Quantification of the Compounds of the Ethanolic Extract from Caesalpinia ferrea Stem Bark and Evaluation of Their Mutagenic Activity
por: Wyrepkowski, Carlos César, et al.
Publicado: (2014)

The Salmonella Mutagenicity Assay: The Stethoscope of Genetic Toxicology for the 21st Century
por: Claxton, Larry D., et al.
Publicado: (2010)

Estrogenic and mutagenic activities of Crotalaria pallida measured by recombinant yeast assay and Ames test
por: Boldrin, Paula Karina, et al.
Publicado: (2013)

Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts
por: Calvo, Tamara Regina, et al.
Publicado: (2011)

Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test
por: Espanha, Lívia Greghi, et al.
Publicado: (2014)

Detection by replica plating of false revertant colonies induced in the Salmonella-mammalian microsome assay by hexavalent chromium.
por: Pedersen, P, et al.
Publicado: (1983)

Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay
por: Mölzer, C., et al.
Publicado: (2013)

Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MS(n) and Their Mutagenic Activity
por: Zanutto, Fabiana Volpe, et al.
Publicado: (2012)

Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo
por: Oliveira, R.J., et al.
Publicado: (2014)

Statistical characterization of negative control data in the Ames Salmonella/microsome test.
por: Hamada, C, et al.
Publicado: (1994)

Testing the environment for dispersed mutagens: use of plant bioconcentrators coupled with microbial mutagen assays.
por: Barnes, W S, et al.
Publicado: (1978)

Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease
por: Pavan, Aline Renata, et al.
Publicado: (2022)

Statistical analysis of data in mutagenicity assays: rodent micronucleus assay.
por: Hayashi, M, et al.
Publicado: (1994)

Mutagenicity comparison of nine bioselenocompounds in three Salmonella typhimurium strains
por: Kobayashi, Hironori, et al.
Publicado: (2018)

Mutagenicity assessment of Salacia chinensis by bacterial reverse mutation assay using histidine dependent Salmonella typhimurium tester strains
por: Reddi Nagesh, Madhuranthakam, et al.
Publicado: (2022)

Mutagenic metabolites of benzene detected in the Microscreen assay.
por: Rossman, R G, et al.
Publicado: (1989)

Mutagenicity and metabolism of vinyl chloride and related compounds.
por: Bartsch, H, et al.
Publicado: (1976)

Comparative Studies of the (Anti) Mutagenicity of Baccharis dracunculifolia and Artepillin C by the Bacterial Reverse Mutation Test
por: Resende, Flávia Aparecida, et al.
Publicado: (2012)

The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part II: Assay performance for the identification of mutagenic chemicals
por: Cox, Julie A., et al.
Publicado: (2019)

Evaluation of the mutagenicity and antimutagenicity of Ziziphus joazeiro Mart. bark in the micronucleus assay
por: Boriollo, Marcelo Fabiano Gomes, et al.
Publicado: (2014)

Screening aquatic ecosystems for mutagens with fern bio-assays
por: Klekowski, Edward J.
Publicado: (1978)

Mutagenicity of PCBs and their pyrosynthetic derivatives in cell-mediated assay.
por: Hattula, M L
Publicado: (1985)

Mutagenic Assessment of Olmesartan Cilexetil by Bacterial Mutation Assay
por: Kim, Ji Won, et al.
Publicado: (2013)

Evaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests
por: Tsuboy, Marcela Stefanini, et al.
Publicado: (2010)

Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test
por: Damasceno, Jaqueline Lopes, et al.
Publicado: (2019)

Prediction of Transformation Products of Monensin by Electrochemistry Compared to Microsomal Assay and Hydrolysis
por: Kotthoff, Lisa, et al.
Publicado: (2019)

The nature of the mutagenicity and carcinogenicity of nitrated, aromatic compounds in the environment.
por: Tokiwa, H, et al.
Publicado: (1987)

Toxicity, uptake, and mutagenicity of particulate and soluble nickel compounds.
por: Fletcher, G G, et al.
Publicado: (1994)

Evaluation of mutagenicity testing with Salmonella typhimurium TA102 in three different laboratories.
por: Müller, W, et al.
Publicado: (1993)

Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particles.
por: DeMarini, David M, et al.
Publicado: (2004)

Nonparametric regression analysis of data from the Ames mutagenicity assay.
por: Cologne, J B, et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_h7knrl021rb0nlud9990v7hka5