Electrostatic hot spot on DNA-binding domains mediates phosphate desolvation and the pre-organization of specificity determinant side chains

A major obstacle towards elucidating the molecular basis of transcriptional regulation is the lack of a detailed understanding of the interplay between non-specific and specific protein–DNA interactions. Based on molecular dynamics simulations of C(2)H(2) zinc fingers (ZFs) and engrailed homeodomain...

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Detalles Bibliográficos
Autores principales: Temiz, Alpay N., Benos, Panayiotis V., Camacho, Carlos J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853105/
https://www.ncbi.nlm.nih.gov/pubmed/20047959
http://dx.doi.org/10.1093/nar/gkp1132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853105/
https://www.ncbi.nlm.nih.gov/pubmed/20047959
http://dx.doi.org/10.1093/nar/gkp1132

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