The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase

Human tyrosyl-DNA phosphodiesterase (Tdp1) processes 3′-blocking lesions, predominantly 3′-phosphotyrosyl bonds resulting from the trapping of topoisomerase I (Top1) cleavage complexes. The controversial ability of yeast Tdp1 to hydrolyze 5′-phosphotyrosyl linkage between topoisomerase II (Top2) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Dexheimer, Thomas S., Stephen, Andrew G., Fivash, Matthew J., Fisher, Robert J., Pommier, Yves
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853120/
https://www.ncbi.nlm.nih.gov/pubmed/20097655
http://dx.doi.org/10.1093/nar/gkp1206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853120/
https://www.ncbi.nlm.nih.gov/pubmed/20097655
http://dx.doi.org/10.1093/nar/gkp1206

Ejemplares similares