MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing

Muscleblind-like 1 (MBNL1) regulates alternative splicing and is a key player in the disease mechanism of myotonic dystrophy (DM). In DM, MBNL1 becomes sequestered to expanded CUG/CCUG repeat RNAs resulting in splicing defects, which lead to disease symptoms. In order to understand MBNL1’s role in b...

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Detalles Bibliográficos
Autores principales: Goers, Emily S., Purcell, Jamie, Voelker, Rodger B., Gates, Devika P., Berglund, J. Andrew
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853123/
https://www.ncbi.nlm.nih.gov/pubmed/20071745
http://dx.doi.org/10.1093/nar/gkp1209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853123/
https://www.ncbi.nlm.nih.gov/pubmed/20071745
http://dx.doi.org/10.1093/nar/gkp1209

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