A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI

Insight into protein structure and function is best obtained through a synthesis of experimental, structural and bioinformatic data. Here, we outline a framework that we call MUSE (mutual information, unigenic evolution and structure-guided elucidation), which facilitated the identification of previ...

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Detalles Bibliográficos
Autores principales: Kleinstiver, Benjamin P., Fernandes, Andrew D., Gloor, Gregory B., Edgell, David R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853131/
https://www.ncbi.nlm.nih.gov/pubmed/20061372
http://dx.doi.org/10.1093/nar/gkp1223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853131/
https://www.ncbi.nlm.nih.gov/pubmed/20061372
http://dx.doi.org/10.1093/nar/gkp1223

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