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A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI
Insight into protein structure and function is best obtained through a synthesis of experimental, structural and bioinformatic data. Here, we outline a framework that we call MUSE (mutual information, unigenic evolution and structure-guided elucidation), which facilitated the identification of previ...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853131/ https://www.ncbi.nlm.nih.gov/pubmed/20061372 http://dx.doi.org/10.1093/nar/gkp1223 |