Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2

BACKGROUND: Functional loss of the tumor suppressor Smad4 is involved in pancreatic and colorectal carcinogenesis and has been associated with the acquisition of invasiveness. We have previously demonstrated that the heterotrimeric basement membrane protein laminin-332 is a Smad4 target. Namely, Sma...

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Detalles Bibliográficos
Autores principales: Zboralski, Dirk, Warscheid, Bettina, Klein-Scory, Susanne, Malas, M Bassel, Becker, Heiko, Böckmann, Miriam, Meyer, Helmut E, Schmiegel, Wolff, Simon-Assmann, Patricia, Schwarte-Waldhoff, Irmgard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853515/
https://www.ncbi.nlm.nih.gov/pubmed/20307265
http://dx.doi.org/10.1186/1476-4598-9-65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853515/
https://www.ncbi.nlm.nih.gov/pubmed/20307265
http://dx.doi.org/10.1186/1476-4598-9-65

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