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Discovery of Selective Inhibitors Against EBNA1 via High Throughput In Silico Virtual Screening
BACKGROUND: Epstein-Barr Virus (EBV) latent infection is associated with several human malignancies and is a causal agent of lymphoproliferative diseases during immunosuppression. While inhibitors of herpesvirus DNA polymerases, like gancyclovir, reduce EBV lytic cycle infection, these treatments ha...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853575/ https://www.ncbi.nlm.nih.gov/pubmed/20405039 http://dx.doi.org/10.1371/journal.pone.0010126 |