Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

Autophagy is a cytoprotective pathway used to degrade and recycle cytoplasmic content. Dysfunctional autophagy has been linked to both cancer and cardiomyopathies. Here, we show a role for the transcriptional regulator p8 in autophagy. p8 RNA interference (RNAi) increases basal autophagy markers in...

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Detalles Bibliográficos
Autores principales: Kong, Derek K., Georgescu, Serban P., Cano, Carla, Aronovitz, Mark J., Iovanna, Juan Lucio, Patten, Richard D., Kyriakis, John M., Goruppi, Sandro
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854092/
https://www.ncbi.nlm.nih.gov/pubmed/20181828
http://dx.doi.org/10.1091/mbc.E09-09-0818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854092/
https://www.ncbi.nlm.nih.gov/pubmed/20181828
http://dx.doi.org/10.1091/mbc.E09-09-0818

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