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Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

Autophagy is a cytoprotective pathway used to degrade and recycle cytoplasmic content. Dysfunctional autophagy has been linked to both cancer and cardiomyopathies. Here, we show a role for the transcriptional regulator p8 in autophagy. p8 RNA interference (RNAi) increases basal autophagy markers in...

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Detalles Bibliográficos
Autores principales:	Kong, Derek K., Georgescu, Serban P., Cano, Carla, Aronovitz, Mark J., Iovanna, Juan Lucio, Patten, Richard D., Kyriakis, John M., Goruppi, Sandro
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854092/ https://www.ncbi.nlm.nih.gov/pubmed/20181828 http://dx.doi.org/10.1091/mbc.E09-09-0818

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