Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila

Spinocerebellar ataxia type 5 (SCA5) is an autosomal dominant neurodegenerative disorder caused by mutations in the SPBTN2 gene encoding β-III–spectrin. To investigate the molecular basis of SCA5, we established a series of transgenic Drosophila models that express human β-III–spectrin or fly β-spec...

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Detalles Bibliográficos
Autores principales: Lorenzo, Damaris N., Li, Min-gang, Mische, Sarah E., Armbrust, Karen R., Ranum, Laura P. W., Hays, Thomas S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854382/
https://www.ncbi.nlm.nih.gov/pubmed/20368622
http://dx.doi.org/10.1083/jcb.200905158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854382/
https://www.ncbi.nlm.nih.gov/pubmed/20368622
http://dx.doi.org/10.1083/jcb.200905158

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