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Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids
BACKGROUND: Many Gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is usually flanked N-terminally by arginine and C-terminally by valine. We used this 14-residue sequence as a template to creat...
Autores principales: | Ruchala, Piotr, Navab, Mohamad, Jung, Chun-Ling, Hama-Levy, Susan, Micewicz, Ewa D., Luong, Hai, Reyles, Jonathan E., Sharma, Shantanu, Waring, Alan J., Fogelman, Alan M., Lehrer, Robert I. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854715/ https://www.ncbi.nlm.nih.gov/pubmed/20418958 http://dx.doi.org/10.1371/journal.pone.0010181 |
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