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Peroxisome Proliferator–Activated Receptor-γ Mediates Bisphenol A Inhibition of FSH-Stimulated IGF-1, Aromatase, and Estradiol in Human Granulosa Cells

BACKGROUND: Bisphenol A (BPA), a chemical used as a plasticizer, is a potent endocrine disruptor that, even in low concentrations, disturbs normal development and functions of reproductive organs in different species. OBJECTIVES: We investigated whether BPA affects human ovarian granulosa cell funct...

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Detalles Bibliográficos
Autores principales: Kwintkiewicz, Jakub, Nishi, Yoshihiro, Yanase, Toshihiko, Giudice, Linda C.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854770/
https://www.ncbi.nlm.nih.gov/pubmed/20064783
http://dx.doi.org/10.1289/ehp.0901161