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Prediction of Co-Receptor Usage of HIV-1 from Genotype

Human Immunodeficiency Virus 1 uses for entry into host cells a receptor (CD4) and one of two co-receptors (CCR5 or CXCR4). Recently, a new class of antiretroviral drugs has entered clinical practice that specifically bind to the co-receptor CCR5, and thus inhibit virus entry. Accurate prediction of...

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Detalles Bibliográficos
Autores principales: Dybowski, J. Nikolaj, Heider, Dominik, Hoffmann, Daniel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855328/
https://www.ncbi.nlm.nih.gov/pubmed/20419152
http://dx.doi.org/10.1371/journal.pcbi.1000743