A Multi-Variant, Viral Dynamic Model of Genotype 1 HCV to Assess the in vivo Evolution of Protease-Inhibitor Resistant Variants

Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease inhibitor, telaprevir. Variant fitness was est...

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Detalles Bibliográficos
Autores principales: Adiwijaya, Bambang S., Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D., Garg, Varun, Randle, John C. R., Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855330/
https://www.ncbi.nlm.nih.gov/pubmed/20419154
http://dx.doi.org/10.1371/journal.pcbi.1000745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855330/
https://www.ncbi.nlm.nih.gov/pubmed/20419154
http://dx.doi.org/10.1371/journal.pcbi.1000745

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