1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.

Detalles Bibliográficos
Autores principales: Shin, Jai Moo, Sachs, George, Cho, Young-moon, Garst, Michael
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855619/
https://www.ncbi.nlm.nih.gov/pubmed/20032890
http://dx.doi.org/10.3390/molecules14125247
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author Shin, Jai Moo
Sachs, George
Cho, Young-moon
Garst, Michael
author_facet Shin, Jai Moo
Sachs, George
Cho, Young-moon
Garst, Michael
author_sort Shin, Jai Moo
collection PubMed
description New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
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spelling pubmed-28556192010-12-14 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs Shin, Jai Moo Sachs, George Cho, Young-moon Garst, Michael Molecules Article New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition. Molecular Diversity Preservation International 2009-12-15 /pmc/articles/PMC2855619/ /pubmed/20032890 http://dx.doi.org/10.3390/molecules14125247 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shin, Jai Moo
Sachs, George
Cho, Young-moon
Garst, Michael
1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs
title 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs
title_full 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs
title_fullStr 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs
title_full_unstemmed 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs
title_short 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs
title_sort 1-arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855619/
https://www.ncbi.nlm.nih.gov/pubmed/20032890
http://dx.doi.org/10.3390/molecules14125247
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AT choyoungmoon 1arylsulfonyl2pyridylmethylsulfinylbenzimidazolesasnewprotonpumpinhibitorprodrugs
AT garstmichael 1arylsulfonyl2pyridylmethylsulfinylbenzimidazolesasnewprotonpumpinhibitorprodrugs

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