EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy

BACKGROUND: Cross-talk between receptor tyrosine kinases and the oestrogen receptor (ER) is implicated in resistance to endocrine therapy. We investigated whether AEE788 (a combined inhibitor of EGFR, HER2 and VEGFR) plus tamoxifen or letrozole enhanced the individual anti-tumour effects of these ag...

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Detalles Bibliográficos
Autores principales: Evans, A H, Pancholi, S, Farmer, I, Thornhill, A, Evans, D B, Johnston, S R, Dowsett, M, Martin, L-A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856013/
https://www.ncbi.nlm.nih.gov/pubmed/20386540
http://dx.doi.org/10.1038/sj.bjc.6605641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856013/
https://www.ncbi.nlm.nih.gov/pubmed/20386540
http://dx.doi.org/10.1038/sj.bjc.6605641

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