Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers

BACKGROUND: Telomeres, located at chromosome ends, are progressively shortened during each cell cycle by replication-dependent loss of DNA termini. Although maintenance of telomere length is critical for cell-replicative potential and tumourigenesis, the erosion of telomeres can lead to genetic inst...

Descripción completa

Detalles Bibliográficos
Autores principales: Rampazzo, E, Bertorelle, R, Serra, L, Terrin, L, Candiotto, C, Pucciarelli, S, Bianco, P Del, Nitti, D, De Rossi, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856015/
https://www.ncbi.nlm.nih.gov/pubmed/20386541
http://dx.doi.org/10.1038/sj.bjc.6605644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856015/
https://www.ncbi.nlm.nih.gov/pubmed/20386541
http://dx.doi.org/10.1038/sj.bjc.6605644

Ejemplares similares