Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

Endothelial cell–cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell–ce...

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Detalles Bibliográficos
Autores principales: Stockton, Rebecca A., Shenkar, Robert, Awad, Issam A., Ginsberg, Mark H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856024/
https://www.ncbi.nlm.nih.gov/pubmed/20308363
http://dx.doi.org/10.1084/jem.20091258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856024/
https://www.ncbi.nlm.nih.gov/pubmed/20308363
http://dx.doi.org/10.1084/jem.20091258

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