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Interactions Between a Voltage Sensor and a Toxin via Multiscale Simulations
Gating-modifier toxins inhibit voltage-gated ion channels by binding the voltage sensors (VS) and altering the energetics of voltage-dependent gating. These toxins are thought to gain access to the VS via the membrane (i.e., by partitioning from water into the membrane before binding the VS). We use...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856169/ https://www.ncbi.nlm.nih.gov/pubmed/20409475 http://dx.doi.org/10.1016/j.bpj.2009.12.4321 |