Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

BACKGROUND: Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However, drug delivery into primary brain tumors and metastases is impeded by the blood-brain tumor barrier (BTB), significantly limiting drug use in b...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Jinwei, Ljubimova, Julia Y., Inoue, Satoshi, Konda, Bindu, Patil, Rameshwar, Ding, Hui, Espinoza, Andres, Wawrowsky, Kolja A., Patil, Chirag, Ljubimov, Alexander V., Black, Keith L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856671/
https://www.ncbi.nlm.nih.gov/pubmed/20419092
http://dx.doi.org/10.1371/journal.pone.0010108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856671/
https://www.ncbi.nlm.nih.gov/pubmed/20419092
http://dx.doi.org/10.1371/journal.pone.0010108

Ejemplares similares