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Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells
The mechanism of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in cancer cells is not fully understood. Here, we show that the Akt survival pathway plays an important role in TRAIL resistance in human cancer cells. Specifically, we found that TRAIL treatment activates th...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856686/ https://www.ncbi.nlm.nih.gov/pubmed/20419107 http://dx.doi.org/10.1371/journal.pone.0010226 |