Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS

The DNA mismatch repair protein MutS acts as a molecular switch. It toggles between ADP and ATP states and is regulated by mismatched DNA. This is analogous to G-protein switches and the regulation of their “on” and “off” states by guanine exchange factors. Although GDP release in monomeric GTPases...

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Detalles Bibliográficos
Autores principales: Lebbink, Joyce H. G., Fish, Alexander, Reumer, Annet, Natrajan, Ganesh, Winterwerp, Herrie H. K., Sixma, Titia K.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
DNA and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857095/
https://www.ncbi.nlm.nih.gov/pubmed/20167596
http://dx.doi.org/10.1074/jbc.M109.066001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857095/
https://www.ncbi.nlm.nih.gov/pubmed/20167596
http://dx.doi.org/10.1074/jbc.M109.066001

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