Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation via derepression of Chk1 catalytic activity

Chk1 is phosphorylated within its C-terminal regulatory domain by the upstream ATM/ ATR kinases during checkpoint activation, however how this modulates Chk1 function is poorly understood. Here, we show that Chk1 kinase activity is rapidly stimulated in a cell cycle phase-specific manner in response...

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Detalles Bibliográficos
Autores principales: Walker, M, Black, EJ, Oehler, V, Gillespie, DA, Scott, MT
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857325/
https://www.ncbi.nlm.nih.gov/pubmed/19421147
http://dx.doi.org/10.1038/onc.2009.102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857325/
https://www.ncbi.nlm.nih.gov/pubmed/19421147
http://dx.doi.org/10.1038/onc.2009.102

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