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Effects of Tetrodotoxin on the Mammalian Cardiovascular System

The human genome encodes nine functional voltage-gated Na(+) channels. Three of them, namely Na(v)1.5, Na(v)1.8, and Na(v)1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC(50) ≥ 1 μM). The other isoforms, which are predominantly expressed in the skeletal muscle and nervous syst...

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Detalles Bibliográficos
Autor principal: Zimmer, Thomas
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857368/
https://www.ncbi.nlm.nih.gov/pubmed/20411124
http://dx.doi.org/10.3390/md8030741