Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function

Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the cell cycle, it is expected the development of a potent, selective small molecule inh...

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Detalles Bibliográficos
Autores principales: Kwiatkowski, Nicholas, Jelluma, Nannette, Filippakopoulos, Panagis, Soundararajan, Meera, Manak, Michael S., Kwon, Mijung, Choi, Hwan Geun, Sim, Taebo, Deveraux, Quinn L., Rottmann, Sabine, Pellman, David, Shah, Jagesh V., Kops, Geert J.P.L., Knapp, Stefan, Gray, Nathanael S.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857554/
https://www.ncbi.nlm.nih.gov/pubmed/20383151
http://dx.doi.org/10.1038/nchembio.345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857554/
https://www.ncbi.nlm.nih.gov/pubmed/20383151
http://dx.doi.org/10.1038/nchembio.345

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